Bidirectional Clinical-Lab Approach
Lab & Clinic
The Bidirectional Clinical-Lab Approach involves working backwards from clinical observations to understand the underlying mechanisms of a disease, and then using that knowledge to inform the development of new treatments. This approach requires close collaboration between clinicians and researchers, and can lead to the discovery of new uses for existing drugs.
- Clinical observations should inform laboratory research
- Laboratory findings should be translated back into clinical practice
- A bidirectional approach can accelerate drug discovery and development
- Identify a clinical observation or unmet medical needStart by identifying a clinical observation or unmet medical need that could be addressed through the development of a new treatment.Pro tipLook for areas where existing treatments are not effective or are poorly toleratedWarningBe aware of the potential risks and challenges associated with developing a new treatment
- Conduct laboratory research to understand the underlying mechanismsUse laboratory research to understand the underlying mechanisms of the disease or condition, and to identify potential targets for intervention.Pro tipUse a variety of research techniques, including cell culture, animal models, and bioinformaticsWarningBe aware of the potential limitations and biases of laboratory research
- Translate laboratory findings back into clinical practiceTake the findings from laboratory research and translate them back into clinical practice, using techniques such as clinical trials and observational studies.Pro tipWork closely with clinicians and patients to ensure that the treatment is effective and safeWarningBe aware of the potential risks and challenges associated with translating laboratory findings into clinical practice
Dr. Fajgenbaum's own experience with Castleman's disease
Dr. Fajgenbaum used the Bidirectional Clinical-Lab Approach to develop a new treatment for his own Castleman's disease, and has since applied this approach to help other patients.
OutcomeThe development of a new treatment for Castleman's disease, and the improvement of patient outcomes.
Failing to consider the potential risks and challenges
Failing to consider the potential risks and challenges associated with developing a new treatment can lead to unintended consequences and harm to patients.
Not working closely with clinicians and patients
Not working closely with clinicians and patients can lead to a lack of understanding of the clinical context and the needs of patients.
Dr. Fajgenbaum developed this approach through his own experience with Castleman's disease, and has since applied it to help other patients with rare and debilitating conditions.
Source · PODCAST
How A Doctor Cured His Own Terminal Disease | Dr. David Fajgenbaum