PEAK PERFORMANCEMonths to result

Glymphatic Clearance Framework

Clearing brain junk

Problem it solves

Glymphatic Clearance Framework solves the gap between potential and actual performance by providing a structured approach to measuring, improving, and sustaining high output.

Best for

Individuals seeking to improve brain health and reduce risk of neurodegenerative diseases

Not ideal for

Those with underlying medical conditions or taking certain medications

Overview

Why this framework exists

The Glymphatic Clearance Framework refers to the process by which the brain clears waste and toxins during sleep. Research has shown that this process is impaired in aging brains and may contribute to neurodegenerative diseases. By prioritizing sleep and using techniques such as intermittent fasting, individuals can potentially improve glymphatic clearance and promote brain health.

Core principles

3 total
  1. Sleep is essential for brain health and waste clearance
  2. Intermittent fasting can improve glymphatic clearance
  3. Exercise and physical activity can also promote brain health

Steps

3 steps
  1. Prioritize Sleep
    Aim for 7-9 hours of sleep per night to allow for optimal glymphatic clearance. Establish a consistent sleep schedule and create a sleep-conducive environment.
    Pro tipAvoid screens and electronic devices before bedtime
    WarningSleep deprivation can have negative effects on brain health
  2. Incorporate Intermittent Fasting
    Try incorporating intermittent fasting into your routine, such as 12-14 hours of fasting per day. This can help improve glymphatic clearance and promote brain health.
    Pro tipStart with shorter fasting periods and gradually increase duration
    WarningConsult with a healthcare professional before starting any new fasting regimen
  3. Engage in Regular Exercise
    Regular exercise, such as cardio and resistance training, can help promote brain health and improve glymphatic clearance. Aim for at least 30 minutes of moderate-intensity exercise per day.
    Pro tipFind an exercise routine that you enjoy and can stick to
    WarningConsult with a healthcare professional before starting any new exercise program

Checklist

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Examples

1 cases
Case Study: Improving Brain Health through Sleep and Intermittent Fasting

A 50-year-old individual with a history of sleep deprivation and poor diet began prioritizing sleep and incorporating intermittent fasting into their routine. After 6 months, they reported improved cognitive function and reduced risk of neurodegenerative diseases.

OutcomeImproved brain health and reduced risk of neurodegenerative diseases

Common mistakes

2 traps
Not Prioritizing Sleep
Failing to prioritize sleep can lead to impaired glymphatic clearance and negative effects on brain health.
Overdoing Intermittent Fasting
Overdoing intermittent fasting can lead to nutrient deficiencies and negative effects on overall health.

Origin story

How this framework came to be

The concept of glymphatic clearance was first discovered in 2012 by a team of researchers at the University of Rochester. Since then, numerous studies have explored the mechanisms and importance of glymphatic clearance in maintaining brain health.

Source

Traced to primary
Source · PODCAST
Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray
Andrew Huberman · 2026
Open source →