PEAK PERFORMANCEWeeks to result

Glymphatic System Framework

Clearing brain debris

Problem it solves

Leaders who struggle to develop a clear, actionable approach to glymphatic system framework, resulting in inconsistent team performance and missed organizational potential.

Best for

Individuals with TBI or concerned about brain longevity

Not ideal for

Those who cannot engage in zone 2 cardio or have certain medical conditions

Overview

Why this framework exists

The glymphatic system is a newly discovered system that clears waste from the brain, particularly during sleep. Exercise, such as zone 2 cardio, and sleeping on one's side can enhance its function. This framework provides a structured approach to understanding and utilizing the glymphatic system for brain health and pain management.

Core principles

3 total
  1. The glymphatic system is essential for clearing brain debris and promoting brain health.
  2. Exercise, such as zone 2 cardio, can enhance glymphatic system function.
  3. Sleeping on one's side can increase glymphatic system activity.

Steps

2 steps
  1. Engage in zone 2 cardio
    Perform zone 2 cardio for 30-45 minutes, three times a week, to enhance glymphatic system function.
    Pro tipConsult with a physician before starting any new exercise program.
    WarningAvoid exercising if it aggravates your injury or goes against your physician's advice.
  2. Sleep on your side
    Sleep on your side to increase glymphatic system activity and promote brain health.
    Pro tipUse a supportive pillow to maintain proper spinal alignment.
    WarningAvoid sleeping on your stomach or back, as this can reduce glymphatic system activity.

Checklist

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Examples

1 cases
TBI recovery

An individual with TBI engages in zone 2 cardio and sleeps on their side, resulting in improved brain health and reduced pain.

OutcomeImproved cognitive function and reduced pain

Common mistakes

2 traps
Not getting enough sleep
Failing to get adequate sleep can reduce glymphatic system function and negatively impact brain health.
Exercising too intensely
Exercising too intensely can exacerbate injury or negatively impact brain health.

Origin story

How this framework came to be

The glymphatic system was first discovered in 2012, and since then, research has shown its importance in clearing brain debris and promoting brain health. Andrew Huberman discusses the implications of this system for TBI and brain longevity.

Source

Traced to primary
Source · PODCAST
Control Pain & Heal Faster With Your Brain | Huberman Lab Essentials
Andrew Huberman · 2025
Open source →