PEAK PERFORMANCEDays to result

Prolactin Suppression Framework

Suppress prolactin to mitigate crash

Problem it solves

Helps sustain motivation and overcome resistance to action

Best for

Individuals experiencing post-MDMA crash

Not ideal for

Those with underlying hormonal imbalances

Overview

Why this framework exists

The Prolactin Suppression Framework suggests that suppressing prolactin levels can help mitigate the negative effects of the post-MDMA crash. This framework is based on the idea that increased prolactin levels contribute to the crash, and that reducing these levels can help alleviate symptoms such as lethargy and decreased motivation.

Core principles

3 total
  1. Prolactin levels increase after MDMA ingestion
  2. Increased prolactin levels contribute to post-MDMA crash
  3. Suppressing prolactin levels can help mitigate crash symptoms

Steps

3 steps
  1. Assess prolactin levels
    Measure prolactin levels after MDMA ingestion to determine the extent of the increase.
    Pro tipUse a reliable testing method to ensure accurate results.
    WarningBe aware of potential false positives or false negatives.
  2. Choose a prolactin suppression method
    Select a method to suppress prolactin levels, such as using p5p or other vitamin B6 derivatives.
    Pro tipConsult with a healthcare professional to determine the best method for individual needs.
    WarningBe cautious of potential side effects or interactions with other medications.
  3. Monitor and adjust
    Continuously monitor prolactin levels and adjust the suppression method as needed to achieve optimal results.
    Pro tipKeep a record of prolactin levels and symptoms to track progress.
    WarningBe aware of potential over-suppression or under-suppression of prolactin levels.

Checklist

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Examples

1 cases
Case study: P5P supplementation

A study found that individuals who took p5p supplements after MDMA ingestion experienced reduced prolactin levels and alleviated crash symptoms.

OutcomeThe study suggested that p5p supplementation may be an effective method for suppressing prolactin levels and mitigating post-MDMA crash.

Common mistakes

2 traps
Over-suppression of prolactin
Over-suppressing prolactin levels can lead to negative side effects, such as decreased libido or mood changes.
Under-suppression of prolactin
Under-suppressing prolactin levels may not effectively mitigate crash symptoms, leading to continued negative effects.

Origin story

How this framework came to be

The Prolactin Suppression Framework originated from research on the neurochemical effects of MDMA, which showed that the drug increases prolactin levels. Further research suggested that suppressing prolactin levels could help mitigate the negative effects of the crash.

Source

Traced to primary
Source · PODCAST
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
Andrew Huberman · 2023
Open source →