PEAK PERFORMANCEWeeks to result

Psychedelic-Assisted Therapy

Therapy with psychedelics

Problem it solves

Suboptimal health habits undermine energy, performance, and longevity; this framework provides specific evidence-based practices to build a sustainable physical and mental health foundation.

Best for

Individuals with treatment-resistant mental health conditions

Not ideal for

Individuals with a history of psychotic disorders or cardiovascular disease

Overview

Why this framework exists

Psychedelic-assisted therapy is a form of therapy that uses psychedelics, such as psilocybin, to facilitate deep emotional and psychological exploration. The therapy is typically conducted in a controlled environment with a trained therapist and involves preparation, administration of the psychedelic, and integration of the experience. The goal of the therapy is to help individuals process and overcome traumatic experiences, negative thought patterns, and behaviors.

Core principles

3 total
  1. The therapeutic relationship is a critical component of psychedelic-assisted therapy.
  2. The psychedelic experience should be approached with an open and non-judgmental mindset.
  3. The integration of the psychedelic experience is essential for long-term benefits.

Steps

3 steps
  1. Preparation
    The individual undergoes a thorough screening and preparation process, including psychiatric interviews and cardiovascular screening.
    Pro tipIt is essential to establish a strong therapeutic relationship with the guide or therapist.
    WarningIndividuals with a history of psychotic disorders or cardiovascular disease may not be suitable for psychedelic-assisted therapy.
  2. Administration of the Psychedelic
    The individual is administered a controlled dose of the psychedelic in a safe and supportive environment.
    Pro tipThe guide or therapist should be experienced in facilitating psychedelic experiences.
    WarningThe individual should be closely monitored for any adverse reactions.
  3. Integration
    The individual undergoes a process of integration, where they reflect on their experience and process any insights or emotions that arose during the therapy.
    Pro tipThe integration process should be facilitated by a trained therapist.
    WarningThe individual may experience intense emotions or challenging thoughts during the integration process.

Checklist

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Examples

1 cases
Case Study 1

A 35-year-old woman with treatment-resistant depression underwent psychedelic-assisted therapy with psilocybin. She reported a significant reduction in depressive symptoms and improved mood.

OutcomeThe woman was able to return to work and engage in activities she had previously enjoyed.

Common mistakes

2 traps
Inadequate Preparation
Inadequate preparation can lead to a negative or overwhelming experience.
Insufficient Support
Insufficient support during and after the experience can lead to adverse reactions or inadequate integration.

Origin story

How this framework came to be

The use of psychedelics in therapy dates back to the 1950s and 1960s, but it was largely discontinued due to concerns about safety and efficacy. However, in recent years, there has been a resurgence of interest in psychedelic-assisted therapy, with studies showing promising results for the treatment of mental health conditions such as depression, anxiety, and PTSD.

Source

Traced to primary
Source · PODCAST
Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
Andrew Huberman · 2025
Open source →