PEAK PERFORMANCEMonths to result

The Insulin Regulation Framework

Regulate insulin for better health

Problem it solves

suboptimal performance despite available potential

Best for

Patients with PCOS and insulin resistance

Not ideal for

Patients with normal insulin levels

Overview

Why this framework exists

The Insulin Regulation Framework is a approach to managing insulin resistance in patients with PCOS. It involves using medications such as metformin and GLP-1s to regulate insulin levels and improve symptoms. This framework is based on the idea that insulin resistance is a key factor in the development of PCOS and that regulating insulin levels can improve fertility, weight loss, and overall health.

Core principles

3 total
  1. Insulin resistance is a key factor in the development of PCOS.
  2. Regulating insulin levels can improve fertility, weight loss, and overall health.
  3. Medications such as metformin and GLP-1s can be used to regulate insulin levels.

Steps

4 steps
  1. Diagnose insulin resistance
    Use blood tests to diagnose insulin resistance in patients with PCOS.
    Pro tipUse a combination of blood tests, including fasting insulin and glucose levels, to diagnose insulin resistance.
    WarningInsulin resistance can be difficult to diagnose, so it's essential to use a combination of tests.
  2. Start with supplements
    Start with supplements such as vitamin D, curcumin, and chromium to improve insulin sensitivity.
    Pro tipUse a combination of supplements to improve insulin sensitivity.
    WarningSupplements may not be enough to regulate insulin levels in all patients.
  3. Add metformin
    Add metformin to the treatment plan if supplements are not enough to regulate insulin levels.
    Pro tipStart with a low dose of metformin and gradually increase as needed.
    WarningMetformin can cause side effects such as nausea and diarrhea.
  4. Add GLP-1s
    Add GLP-1s to the treatment plan if metformin is not enough to regulate insulin levels.
    Pro tipStart with a low dose of GLP-1s and gradually increase as needed.
    WarningGLP-1s can cause side effects such as nausea and diarrhea.

Checklist

Saved in your browser

Examples

1 cases
Patient with PCOS and insulin resistance

A patient with PCOS and insulin resistance is treated with metformin and GLP-1s, resulting in improved fertility and weight loss.

OutcomeThe patient is able to conceive and has a healthy pregnancy.

Common mistakes

3 traps
Not diagnosing insulin resistance
Not diagnosing insulin resistance can lead to ineffective treatment and poor outcomes.
Not using a combination of treatments
Not using a combination of treatments, such as supplements, metformin, and GLP-1s, can lead to ineffective treatment and poor outcomes.
Not monitoring side effects
Not monitoring side effects can lead to ineffective treatment and poor outcomes.

Origin story

How this framework came to be

The Insulin Regulation Framework was developed by Dr. Thaïs Aliabadi, who has been treating patients with PCOS for many years. She has found that regulating insulin levels is a key factor in improving symptoms and fertility in these patients.

Source

Traced to primary
Source · PODCAST
Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi
Andrew Huberman · 2025
Open source →