PEAK PERFORMANCEWeeks to result

The Tripartite Pain Relief Framework

Three-pronged approach to pain relief

Problem it solves

The Tripartite Pain Relief Framework solves the gap between potential and actual performance by providing a structured approach to measuring, improving, and sustaining high output.

Best for

Individuals seeking alternative pain relief methods

Not ideal for

Those who require immediate or intense pain relief

Overview

Why this framework exists

The Tripartite Pain Relief Framework involves the simultaneous interaction of three neurotransmitter systems: opioid, serotonin, and adinuric. This framework is based on the idea that targeting multiple pathways can provide more effective pain relief with fewer side effects. Kratom, a natural plant-based substance, has been found to interact with these systems, making it a potential candidate for pain relief.

Core principles

3 total
  1. The opioid system plays a role in pain relief, but it is not the only factor.
  2. The serotonin system is involved in mood regulation and pain processing.
  3. The adinuric system is responsible for stimulant activity and can contribute to pain relief.

Steps

3 steps
  1. Understand the neurotransmitter systems involved
    Learn about the opioid, serotonin, and adinuric systems and their roles in pain relief and processing.
    Pro tipConsider consulting with a healthcare professional to determine the best approach for individual needs.
    WarningBe cautious when using kratom or other substances that interact with these systems, as they can have varying effects on different people.
  2. Explore kratom as a potential pain relief option
    Research the effects of kratom on the opioid, serotonin, and adinuric systems and its potential as a pain relief agent.
    Pro tipLook for high-quality, pure kratom products to minimize the risk of adverse effects.
    WarningBe aware of the potential for addiction or dependence on kratom, especially when used in large quantities or for extended periods.
  3. Consider the importance of dosage and individual response
    Understand that the effects of kratom can vary greatly depending on the dose and individual response.
    Pro tipStart with low doses and gradually increase as needed to minimize the risk of adverse effects.
    WarningBe cautious when combining kratom with other substances, as interactions can occur.

Checklist

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Examples

1 cases
Kratom for chronic pain management

A person with chronic pain finds relief using kratom, which interacts with their opioid, serotonin, and adinuric systems to provide effective pain management.

OutcomeThe individual experiences significant pain reduction and improved quality of life.

Common mistakes

2 traps
Overlooking the complexity of the neurotransmitter systems
Failing to consider the intricate relationships between the opioid, serotonin, and adinuric systems can lead to ineffective or even harmful pain relief strategies.
Ignoring the potential for addiction or dependence
Underestimating the risk of addiction or dependence on kratom or other substances can result in serious consequences for individuals.

Origin story

How this framework came to be

The framework was developed through research on kratom and its effects on the human body. Scientists discovered that kratom's alkaloids interact with multiple neurotransmitter systems, leading to a unique pain relief profile.

Source

Traced to primary
Source · PODCAST
Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy
Andrew Huberman · 2025
Open source →